Investigating Potential Drug-Drug Interactions from Greek e-Prescription Data.

BACKGROUND: The prevalence of potential drug-drug interactions (pDDIs) is indicative of the prevalence of actual drug-drug interactions and prescription quality. However, they are significantly understudied in Greece. OBJECTIVE: The objective of the study was to determine the prevalence of pDDIs among outpatients and identify factors associated with their occurrence. METHODS: Anonymous e-prescription data between 2012 and 2017 were obtained from community pharmacies in Thessaloniki, Greece. Patients taking more than one medication for at least three months were included. pDDIs were identified and categorized depending on their clinical significance using Drug Interactions Checker. Crude and adjusted odds ratios (ORs) with accompanying 95% confidence intervals (CIs) of risk factors of pDDIs occurrence were identified using multivariable logistic regression. RESULTS: During the study period, 6,000 anonymous e-prescriptions (1,000 per year) satisfying the inclusion criteria were collected. The overall prevalence of major pDDIs was 17.4% (63.0% for moderate pDDIs). The most common major pDDIs were between amlodipine and simvastatin (22.8% of major interactions), followed by clopidogrel and omeprazole (6.4% of major interactions). Polypharmacy (≥5 concomitantly received medications) was associated with an increased risk of major pDDIs (adjusted OR, 5.72; 95% CI, 4.87-6.72); no associations were observed regarding age, sex, and number of prescribing physicians. CONCLUSION: The prevalence of pDDIs in this study was higher than previously reported in other European countries, with polypharmacy being a potential risk factor. Those results argue for a need for improvement in the area of prescribing in Greece.

Estimating Consumers' Knowledge and Attitudes Towards Over-The-Counter Analgesic Medication in Greece in the Years of Financial Crisis: The Case of Paracetamol.

INTRODUCTION: Non-prescription over-the-counter (OTC) drugs are widely used by patients to control aches, pain, and fever. One of the most frequently used OTC medications worldwide is paracetamol (acetaminophen). The aim of the present study was to fill the current knowledge gap regarding the beliefs and attitudes of people in Greece associated with the use of paracetamol during the years of financial crisis. METHODS: The present study employed a sample of individuals visiting community pharmacies in the second largest city of Greece, Thessaloniki. All participants anonymously answered a questionnaire regarding their beliefs and characteristics of paracetamol consumption. Their answers were then statistically analyzed. RESULTS: The generic paracetamol compound was shown to be more well known than the original. A significant percentage of participants, ranging between 9.9% and 33.7%, falsely believed that certain medications [mainly non-steroidal anti-inflammatory drugs (NSAIDs)] contained paracetamol. Participants' age, level of education, and gender were shown to be predictive of this false belief. Additionally, 11.1% of participants believed that the maximum allowed daily dose of paracetamol was higher than the correct one. Better educated individuals were less likely to consume alcohol in parallel with paracetamol (odd ratio 0.230, 95% confidence interval 0.058-0.916, P = 0.037). CONCLUSION: Paracetamol is commonly used, both in its original and generic forms. However, a significant number of individuals confuse it with NSAIDs. Age, level of education, and gender are important determinants of the characteristics of paracetamol consumption. It seems that patients prefer to take paracetamol on their own decision during the financial crisis.